Bioisosters are substituents or groups with similar physical or chemical properties that produce broadly similar biological properties to other chemical compounds. The relation between bioisosteres is known as bioisosterism In drug design, exchanging one bioisoster for another enhances a compound’s desired biological or physical properties without making significant changes in chemical structure. For example Bioisosters … Read more
Drug metabolism refers to the biochemical processes by which the body chemically modifies pharmaceutical compounds to make them more water-soluble and easier to eliminate from the body. Here’s a breakdown of drug metabolism: A. Purpose of Drug Metabolism: Drug metabolism serves several purposes in the body: B. Sites of Metabolism: C. Phases of Drug Metabolism: … Read more
Stereochemistry involves the study of the three-dimensional nature of molecules. It is the study of the chiral molecules. Conformational Isomers: Different arrangements of atoms that can be converted into one another by rotation about single bonds are called conformations. Rotation about bonds allows the inter-conversion of conformers. A classic example is acetylcholine, which can exist … Read more
The various physiochemical properties affecting the drug action are- 1. Ionization 5. Protein bonding 2. Solubility 6. Chelation 3. Partition coefficient 7. Bioisosterism 4. Hydrogen bonding 8. Stereoisomerism Ionization: It is necessary to know whether a molecule will be ionized at a given pH simply by knowing if the functional groups on the … Read more
The biological membrane (or cell membrane and plasma membrane) is a selectively permeable membrane that allows only certain substances to pass through it and acts as a barrier between the inner and outer surfaces of the cell. Cell membrane comprises lipids and proteins along with other living molecules, which participate in the normal functioning of … Read more
Medicinal chemistry roots can be found in the fertile mix of ancient folk medicine and early natural product chemistry, hence its name. As appreciation for the links between chemical structure and observed biological activity grew, medicinal chemistry began to emerge about 150 years ago as a distinct discipline intending to explore these relationships via chemical … Read more
An agonist and an antagonist are two types of molecules that interact with receptors in the body, but they have opposite effects on the receptor and its downstream signaling pathways. Agonists: An agonist is a chemical that bind to a receptor and activates the receptor to produce a biological response. For example, Heroin, methadone, morphine … Read more
A receptor is a specialized protein molecule, typically found on the surface of a cell or within its interior, that is capable of binding to specific signaling molecules called ligands. Receptors play a crucial role in cellular communication and signal transduction, serving as molecular switches that initiate cellular responses to extracellular stimuli. Or Receptor is … Read more
Medicinal Chemistry is the branch of science that deals with the modification and synthesis of drug molecules. Or Medicinal chemistry is the chemistry discipline concerned with design, development and synthesis of pharmaceutical drugs. Medicinal chemistry lies at the intersection of chemistry, biology, and pharmacology, focusing on the design, synthesis, and development of pharmaceutical agents with … Read more
