Methdilazine (Tacaryl HCl)

Introduction

Methdilazine recognized for its role as an antihistamine, stands as a pharmacological ally in the alleviation of symptoms associated with allergic reactions. Operating as an antagonist at H1 histamine receptors, it effectively mitigates the impact of histamine, providing relief from common allergic manifestations like itching, sneezing, and a runny nose.

Structure

Synthesis

Mechanism of action

Methdilazine acts as an antagonist at H1 receptors, blocking the effects of histamine. This inhibition of histamine effectively relieves symptoms linked to allergic reactions, including itching, sneezing, and a runny nose.

Properties and uses: 

It may be used to relieve urticaria. It has also been used successfully for the treatment of migraine headaches and Allergic Rhinitis.

Dose: 

The usual dose for adults is 8 mg, taken orally twice to four times daily.