Piperazine derivatives” refers to a group of chemical compounds that share the basic structural framework of piperazine. Piperazine is a heterocyclic organic compound containing two nitrogen atoms in a six-membered ring. Derivatives of piperazine can be synthesized by modifying this basic structure through various chemical reactions.
Cyclizine (Marezine)
Cyclizine is an antihistamine medication that belongs to the piperazine class of compounds. It is commonly used to prevent and treat nausea, vomiting, and dizziness associated with motion sickness and certain inner ear problems. Cyclizine exerts its effects by blocking the action of histamine at the H1 receptors
Structure
Synthesis
Mechanism of action
- It acts as an H1 receptor antagonist, blocking the effects of histamine.
- It exhibits antimuscarinic (anticholinergic) properties, contributing to its antiemetic effects.
Properties and uses:Â
Cyclizine hydrochloride is a white crystalline powder, slightly soluble in water and alcohol. It is mostly employed as a prophylaxis and for treating motion sickness.
Dose:
The usual dose is 25–100 mg per day.
Dosage forms: Cyclizine HCl tablets I.P., Cyclizine injection B.P., Cyclizine tablets B.P., Dipipanone and cyclizine tablets B.P.
