SAR of Penicillin

The Structure-Activity Relationship (SAR) of penicillin reveals key insights into how modifications in its chemical structure affect its pharmacological properties. From variations in the 6-acyl side chain to the substitution patterns on the α-carbon and modifications of the thiazolidine ring, each alteration can significantly impact the antimicrobial activity, stability, and resistance profile of penicillin derivatives. … Read more